Ontology highlight
ABSTRACT:
SUBMITTER: Wright E
PROVIDER: S-EPMC7015775 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Wright Evan E Miller Joshua J JJ Csordas Matthew M Gosselin Andrew R AR Carter Jared A JA McGrath James L JL Latulippe David R DR Roussie James A JA
Biotechnology and bioengineering 20191218 3
The widely used 0.2/0.22 µm polymer sterile filters were developed for small molecule and protein sterile filtration but are not well-suited for the production of large nonprotein biological therapeutics, resulting in significant yield loss and production cost increases. Here, we report on the development of membranes with isoporous sub-0.2 μm rectangular prism pores using silicon micromachining to produce microslit silicon nitride (MSN) membranes. The very high porosity (~33%) and ultrathin (20 ...[more]