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Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors.


ABSTRACT: Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H-Dots) are demonstrated. H-Dots not only target GIST for image-guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H-Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice following surgical resection. More importantly, IM loaded H-Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H-Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.

SUBMITTER: Kang H 

PROVIDER: S-EPMC7015778 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors.

Kang Homan H   Stiles Wesley R WR   Baek Yoonji Y   Nomura Shinsuke S   Bao Kai K   Hu Shuang S   Park G Kate GK   Jo Min Joo MJ   I Hoseok H   Coll Jean-Luc JL   Rubin Brian P BP   Choi Hak Soo HS  

Advanced materials (Deerfield Beach, Fla.) 20191218 6


Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and  ...[more]

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