Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7016280 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wang Yang Y Jiang Xueyang X Feng Feng F Liu Wenyuan W Sun Haopeng H
Acta pharmaceutica Sinica. B 20190813 2
Blocking the biological functions of scaffold proteins and aggregated proteins is a challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be the solution, considering its ability to selectively degrade target proteins. Recent progress in the PROTAC strategy include identification of the structure of the first ternary eutectic complex, extra-terminal domain-4-PROTAC-Von-Hippel-Lindau (BRD4-PROTAC-VHL), and PROTAC ARV-110 has entered clinical trials for the treatment of p ...[more]