Dataset Information

Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin.

ABSTRACT:

Background

Pseudomonas aeruginosa (Pa) is the predominant pulmonary pathogen in patients with cystic fibrosis (CF). Tobramycin nebulization is used for the eradication of Pa infection. Nowadays, tobramycin dry powder inhalation (DPI) is available as well. This study reports the results of eradicating Pa with tobramycin DPI versus nebulization.

Methods

Adult CF patients with a Pa isolation between September 2010 and September 2017 from the University Medical Centre Groningen (UMCG), the Netherlands, were included in this retrospective study.

Results

In total 27 Pa isolations were recorded. In 13 of these, eradication was attempted with tobramycin, 7 with DPI and 6 with nebulization. DPI eradicated Pa successfully in six isolations (85.7%). Of these, one patient received additional oral ciprofloxacin and one received intravenous ceftazidime. Nebulization eradicated three Pa isolations (50.0%), in two of these, additional oral ciprofloxacin was given.

Conclusion

Eradication rates of DPI tobramycin are comparable with those for nebulized tobramycin reported in the literature. This study suggests that DPI tobramycin is an alternative to nebulized tobramycin for eradication of Pa.

Trial registration

The Medical Ethics Committee of the UMCG granted a waiver (METC2017-349), as they concluded that this study was not subject to the Medical Research Involving Human Subjects Act. The reviews of this paper are available via the supplemental material section.

SUBMITTER: Akkerman-Nijland AM

PROVIDER: S-EPMC7016310 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Eradication of <i>Pseudomonas aeruginosa</i> in cystic fibrosis patients with inhalation of dry powder tobramycin.

Akkerman-Nijland Anne M AM Yousofi Mina M Rottier Bart L BL Van der Vaart Hester H Burgerhof Johannes G M JGM Frijlink Henderik W HW Touw Daan J DJ Koppelman Gerard H GH Akkerman Onno W OW

Therapeutic advances in respiratory disease 20200101

<h4>Background</h4><i>Pseudomonas aeruginosa</i> (<i>Pa</i>) is the predominant pulmonary pathogen in patients with cystic fibrosis (CF). Tobramycin nebulization is used for the eradication of <i>Pa</i> infection. Nowadays, tobramycin dry powder inhalation (DPI) is available as well. This study reports the results of eradicating <i>Pa</i> with tobramycin DPI <i>versus</i> nebulization.<h4>Methods</h4>Adult CF patients with a <i>Pa</i> isolation between September 2010 and September 2017 from the ...[more]

PMID: 32046620

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