Ontology highlight
ABSTRACT:
SUBMITTER: Kulek AR
PROVIDER: S-EPMC7016592 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kulek Andrew R AR Anzell Anthony A Wider Joseph M JM Sanderson Thomas H TH Przyklenk Karin K
Cells 20200115 1
The current standard of care for acute myocardial infarction or 'heart attack' is timely restoration of blood flow to the ischemic region of the heart. While reperfusion is essential for the salvage of ischemic myocardium, re-introduction of blood flow paradoxically <i>kills</i> (rather than rescues) a population of previously ischemic cardiomyocytes-a phenomenon referred to as 'lethal myocardial ischemia-reperfusion (IR) injury'. There is long-standing and exhaustive evidence that mitochondria ...[more]