Ontology highlight
ABSTRACT:
SUBMITTER: Fritz J
PROVIDER: S-EPMC7016638 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Fritz Justine J Lefebvre Olivier O Fernandez Aurore A Schmidt Jordane J Bagnard Dominique D
Cancers 20200108 1
The presence of stromal cells in tumors is altering the significance of molecular profiling when using standard methods of gene expression quantification. We developed a novel normalization method to rank target gene expression in tumor samples by comparisons with reference samples representing the different cell types found in a tumor. The score for each target gene obtained after normalization, is aimed to be predictive of targeted therapies efficiency. We performed this qPCR analysis on human ...[more]