Ontology highlight
ABSTRACT:
SUBMITTER: Di Giorgio ML
PROVIDER: S-EPMC7016701 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Di Giorgio Maria Laura ML Morciano Patrizia P Bucciarelli Elisabetta E Porrazzo Antonella A Cipressa Francesca F Saraniero Sara S Manzi Diana D Rong Yikang S YS Cenci Giovanni G
Cells 20200114 1
The <i>Drosophila melanogaster</i><i>DmATPCL</i> gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. We had previously reported that, although loss of <i>Drosophila</i> ATPCL reduced levels of Acetyl-CoA, unlike its human counterpart, it does not affect globa ...[more]