Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease.
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ABSTRACT:
SUBMITTER: Sironi L
PROVIDER: S-EPMC7016713 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease.
Sironi Lara L Restelli Lisa Michelle LM Tolnay Markus M Neutzner Albert A Frank Stephan S
Cells 20200117 1
The pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation, the dysfunction of various mitochondria-dependent processes has been prominently implicated in PD pathogenesis. Besides the long-known loss of the organelles' bioenergetics function resulting in diminished ATP synthesis, more recent studies in the fiel ...[more]
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