Fibronectin in Cancer: Friend or Foe.
Ontology highlight
ABSTRACT:
SUBMITTER: Lin TC
PROVIDER: S-EPMC7016990 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Fibronectin in Cancer: Friend or Foe.
Lin Tsung-Cheng TC Yang Cheng-Han CH Cheng Li-Hsin LH Chang Wen-Tsan WT Lin Yuh-Rong YR Cheng Hung-Chi HC
Cells 20191220 1
The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic and associated with poor prognosis. Interestingly, FN matrix deposited in the tumor microenvironments (TMEs) promotes tumor progression but is paradoxically related to a better prognosis. Here, we justify how FN impacts tumor transformation and subsequently metastatic progression. Next, we try to reconcile and rationalize ...[more]
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