Ontology highlight
ABSTRACT:
SUBMITTER: Vogel JU
PROVIDER: S-EPMC7017049 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Vogel Jens-Uwe JU Schmidt Sophie S Schmidt Daniel D Rothweiler Florian F Koch Benjamin B Baer Patrick P Rabenau Holger H Michel Detlef D Stamminger Thomas T Michaelis Martin M Cinatl Jindrich J
Cells 20191220 1
The thrombopoietin receptor agonist eltrombopag was successfully used against human cytomegalovirus (HCMV)-associated thrombocytopenia refractory to immunomodulatory and antiviral drugs. These effects were ascribed to the effects of eltrombopag on megakaryocytes. Here, we tested whether eltrombopag may also exert direct antiviral effects. Therapeutic eltrombopag concentrations inhibited HCMV replication in human fibroblasts and adult mesenchymal stem cells infected with six different virus strai ...[more]