Ontology highlight
ABSTRACT:
SUBMITTER: Wang TT
PROVIDER: S-EPMC7017127 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Wang T Tiffany TT Yang Jun J Dighe Shubha S Schmachtenberg Matthew W MW Leigh Nathan T NT Farber Emily E Onengut-Gumuscu Suna S Feith David J DJ Ratan Aakrosh A Loughran Thomas P TP Olson Thomas L TL
Cancers 20200103 1
Large granular lymphocyte (LGL) leukemia arises spontaneously in elderly Fischer (F344) rats. This rodent model has been shown to emulate many aspects of the natural killer (NK) variant of human LGL leukemia. Previous transplantation of leukemic material into young F344 rats resulted in several strains of rat NK (RNK) primary leukemic cells. One strain, RNK-16, was adapted into the RNK-16 cell line and established as an aggressive NK-LGL leukemia model. Whole genome sequencing of the RNK-16 cell ...[more]