Ontology highlight
ABSTRACT:
SUBMITTER: Mazza G
PROVIDER: S-EPMC7017194 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Mazza Giuseppe G Telese Andrea A Al-Akkad Walid W Frenguelli Luca L Levi Ana A Marrali Martina M Longato Lisa L Thanapirom Kessarin K Vilia Maria Giovanna MG Lombardi Benedetta B Crowley Claire C Crawford Mark M Karsdal Morten A MA Leeming Diana J DJ Marrone Giusi G Bottcher Katrin K Robinson Benjamin B Del Rio Hernandez Armando A Tamburrino Domenico D Spoletini Gabriele G Malago Massimo M Hall Andrew R AR Godovac-Zimmermann Jasminka J Luong Tu Vinh TV De Coppi Paolo P Pinzani Massimo M Rombouts Krista K
Cells 20191228 1
An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify and validate new therapeutic targets for HCC. The aim of this work was to validate a new in vitro model based on engineering three-dimensional (3D) healthy and cirrhotic human liver scaffolds with HCC ...[more]