Ontology highlight
ABSTRACT:
SUBMITTER: Pazzaglia S
PROVIDER: S-EPMC7017201 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Pazzaglia Simonetta S Pioli Claudio C
Cells 20191222 1
PARP-1 (poly(ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic inflammation may both predispose to cancer development. On the other hand, inhibition of DNA repair and inflammatory responses can be beneficial in cancer therapy and PARP inhibitors are currently used for their lethal effects on tumor cells. Furthermore, excess of PARP-1 activity has been associated with many tumors and inf ...[more]