Ontology highlight
ABSTRACT:
SUBMITTER: Negreiros-Lima GL
PROVIDER: S-EPMC7017228 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Negreiros-Lima Graziele L GL Lima Kátia M KM Moreira Isabella Z IZ Jardim Bruna Lorrayne O BLO Vago Juliana P JP Galvão Izabela I Teixeira Lívia Cristina R LCR Pinho Vanessa V Teixeira Mauro M MM Sugimoto Michelle A MA Sousa Lirlândia P LP
Cells 20200106 1
Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a manner dependent on PKA and CCR2/CCL2 pathways. Furthermore, db-cAMP promoted reprogramming of bone-marrow-derived macrophages to a M2 phenotype as seen by increased Arg-1/CD206/Ym-1 ...[more]