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Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles.


ABSTRACT: Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.

SUBMITTER: Stevic I 

PROVIDER: S-EPMC7017260 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Monitoring Therapy Efficiency in Cancer through Extracellular Vesicles.

Stevic Ines I   Buescher Gustav G   Ricklefs Franz Lennard FL  

Cells 20200106 1


Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial r  ...[more]

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