Ontology highlight
ABSTRACT:
SUBMITTER: Di Mascolo D
PROVIDER: S-EPMC7017311 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Di Mascolo Daniele D Varesano Serena S Benelli Roberto R Mollica Hilaria H Salis Annalisa A Zocchi Maria Raffaella MR Decuzzi Paolo P Poggi Alessandro A
Cancers 20191231 1
Aminobisphosphonates, such as zoledronic acid (ZA), have shown potential in the treatment of different malignancies, including colorectal carcinoma (CRC). Yet, their clinical exploitation is limited by their high bone affinity and modest bioavailability. Here, ZA is encapsulated into the aqueous core of spherical polymeric nanoparticles (SPNs), whose size and architecture resemble that of biological vesicles. On Vδ2 T cells, derived from the peripheral blood of healthy donors and CRC patients, Z ...[more]