Novel Approaches for Identifying the Molecular Background of Schizophrenia.
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ABSTRACT:
SUBMITTER: Golov AK
PROVIDER: S-EPMC7017322 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Novel Approaches for Identifying the Molecular Background of Schizophrenia.
Golov Arkadiy K AK Kondratyev Nikolay V NV Kostyuk George P GP Golimbet And Vera E AVE
Cells 20200118 1
Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWAS studies to generate biological interpretation of the existing population genetic data, including both molecular (creation and analysis of knockout animals, exploration of the tran ...[more]
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