Phenotypic comparison between smoking and non-smoking chronic obstructive pulmonary disease.

ABSTRACT:

Background

Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clinical, physiological, radiological, sputum cellular and blood biomarkers.

Methods

Two hundred ninety subjects (118 healthy, 79?S-COPD, 93 NS-COPD) performed pre- and post-bronchodilator spirometry and were followed for 2?years to study the annual rate of decline in lung function. Body plethysmography, impulse oscillometry, inspiratory-expiratory HRCT, induced sputum cellular profile and blood biomarkers were compared between 49 healthy, 45?S-COPD and 55 NS-COPD subjects using standardized methods. Spirometric response to oral corticosteroids was measured in 30 female NS-COPD patients.

Results

Compared to all male S-COPD subjects, 47% of NS-COPD subjects were female, were younger by 3.2?years, had greater body mass index, a slower rate of decline in lung function (80 vs 130?mL/year), more small airways obstruction measured by impulse oscillometry (p ConclusionsCompared to S-COPD, NS-COPD is seen in younger subjects with equal male-female predominance, is predominantly a small-airway disease phenotype with less emphysema, preserved lung diffusion and a slower rate of decline in lung function.

SUBMITTER: Salvi SS 

PROVIDER: S-EPMC7017521 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature