Detection and quantification of renal fibrosis by computerized tomography.
Ontology highlight
ABSTRACT: Objectives
Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.Methods
We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates.Results
Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93.Conclusions
This metric is a promising and simple non-invasive biomarker for renal fibrosis.
SUBMITTER: Cohen EP
PROVIDER: S-EPMC7018060 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Detection and quantification of renal fibrosis by computerized tomography.
Cohen Eric P EP Olson John D JD Tooze Janet A JA Bourland J Daniel JD Dugan Greg O GO Cline J Mark JM
PloS one 20200213 2
<h4>Objectives</h4>Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.<h4>Methods</h4>We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates.<h4>Results</h4>Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good dir ...[more]
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