Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

ABSTRACT:

Background/aim

We aimed to investigate the associations between endothelial nitric oxide synthase(eNOS) gene polymorphisms [G894T (rs1799983)], intron 4 (27-bpTR) variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population.

Materials and methods

This case-control study included 112 patients with “stroke of undetermined etiology” and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Between-group frequencies of alleles and genotypes were compared using binary logistic regression analysis.

Results

No significant difference was observed between the two groups in terms of the genotype and allele distributions of the eNOS G894T (rs17999

SUBMITTER: Anlıacık SO 

PROVIDER: S-EPMC7018372 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature