Optimization of interstrand interactions enables burn detection with a collagen-mimetic peptide.
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ABSTRACT:
SUBMITTER: Dones JM
PROVIDER: S-EPMC7018443 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Optimization of interstrand interactions enables burn detection with a collagen-mimetic peptide.
Dones Jesús M JM Tanrikulu I Caglar IC Chacko Jenu V JV Schroeder Alexandra B AB Hoang Trish T TT Gibson Angela L F ALF Eliceiri Kevin W KW Raines Ronald T RT
Organic & biomolecular chemistry 20191101 46
Collagen is an abundant component of the extracellular matrix and connective tissues. Some collagen-mimetic peptides (CMPs) that do not form homotrimers can anneal to damaged tissue. Here, through a computational screen, we identify (flpHypGly)7 as an optimal monomeric CMP for heterotrimer formation. We find that (flpHypGly)7 forms stable triple helices with (ProProGly)7 but not with itself. The nonnatural amino acid HflpOH, which is (2S,4S)-4-fluoroproline, is not toxic to human fibroblasts or ...[more]
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