Ontology highlight
ABSTRACT:
SUBMITTER: Tambini MD
PROVIDER: S-EPMC7018507 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tambini Marc D MD Norris Kelly A KA D'Adamio Luciano L
eLife 20200205
Cleavage of APP by BACE1/β-secretase initiates the amyloidogenic cascade leading to Amyloid-β (Aβ) production. α-Secretase initiates the non-amyloidogenic pathway preventing Aβ production. Several <i>APP</i> mutations cause familial Alzheimer's disease (AD), while the Icelandic <i>APP</i> mutation near the BACE1-cleavage site protects from sporadic dementia, emphasizing APP's role in dementia pathogenesis. To study APP protective/pathogenic mechanisms, we generated knock-in rats carrying either ...[more]