Ontology highlight
ABSTRACT:
SUBMITTER: Wilkinson S
PROVIDER: S-EPMC7018822 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wilkinson Scott S Harmon Stephanie A SA Terrigino Nicholas T NT Karzai Fatima F Pinto Peter A PA Madan Ravi A RA VanderWeele David J DJ Lake Ross R Atway Rayann R Bright John R JR Carrabba Nicole V NV Trostel Shana Y SY Lis Rosina T RT Chun Guinevere G Gulley James L JL Merino Maria J MJ Choyke Peter L PL Ye Huihui H Dahut William L WL Turkbey Baris B Sowalsky Adam G AG
Nature communications 20200213 1
Localized prostate cancers are genetically variable and frequently multifocal, comprising spatially distinct regions with multiple independently-evolving clones. To date there is no understanding of whether this variability can influence management decisions for patients with prostate tumors. Here, we present a single case from a clinical trial of neoadjuvant intense androgen deprivation therapy. A patient was diagnosed with a large semi-contiguous tumor by imaging, histologically composed of a ...[more]