Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia.

ABSTRACT: A diagnosis of schizophrenia is associated with a heterogeneous psychopathology including positive and negative symptoms. The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this hypothesis, previous neuroimaging studies of patients with schizophrenia reported alterations within the default mode network (DMN), the most prominent network at rest. The aim of the present study was to investigate the functional connectivity during rest in patients with schizophrenia and with healthy individuals and explore whether observed functional alterations are related to the psychopathology of patients. Therefore, functional magnetic resonance images at rest were recorded of 35 patients

SUBMITTER: Forlim CG 

PROVIDER: S-EPMC7018974 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature