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Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair.

ABSTRACT: Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

SUBMITTER: Nieuwenhuijs-Moeke GJ

PROVIDER: S-EPMC7019324 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair.

Nieuwenhuijs-Moeke Gertrude J GJ Pischke Søren E SE Berger Stefan P SP Sanders Jan Stephan F JSF Pol Robert A RA Struys Michel M R F MMRF Ploeg Rutger J RJ Leuvenink Henri G D HGD

Journal of clinical medicine 20200117 1

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeut ...[more]

PMID: 31963521

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