Ontology highlight
ABSTRACT:
SUBMITTER: Nieuwenhuijs-Moeke GJ
PROVIDER: S-EPMC7019324 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nieuwenhuijs-Moeke Gertrude J GJ Pischke Søren E SE Berger Stefan P SP Sanders Jan Stephan F JSF Pol Robert A RA Struys Michel M R F MMRF Ploeg Rutger J RJ Leuvenink Henri G D HGD
Journal of clinical medicine 20200117 1
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeut ...[more]