Ontology highlight
ABSTRACT:
SUBMITTER: Jin W
PROVIDER: S-EPMC7019526 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Journal of clinical medicine 20200117 1
Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic neurons of the substantia nigra and plays a critical role in neurophysiological processes, including neuro-protection and maturation and maintenance of neurons. The activation as well as dysfunction of the BDNF-TrkB pathway are associated with neurode ...[more]