Ontology highlight
ABSTRACT:
SUBMITTER: Chambliss JM
PROVIDER: S-EPMC7019864 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Chambliss Jeffrey M JM Ansar Maria M Kelley John P JP Spratt Heidi H Garofalo Roberto P RP Casola Antonella A
Viruses 20200103 1
Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and NRF2 genes have been associated with various lung disorders. To test whether specific NRF2 and/or AOE gene SNPs in children with RSV lower respiratory tract infection were associated with disease sev ...[more]