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Targeting the Host for New Therapeutic Perspectives in Hepatitis D.

ABSTRACT: Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV infected patients (60 million) are co-infected with HDV. Chronic hepatitis D is the most severe form of viral hepatitis with the highest risk to develop cirrhosis and liver cancer. Current treatment is based on pegylated-interferon-alpha which rarely controls HDV infection and is complicated by serious side effects. The development of novel antiviral strategies based on host targeting agents has shown promising results in phase I/II clinical trials. This review summarizes HDV molecular virology and physiopathology as well as new therapeutic approaches targeting HDV host factors.

SUBMITTER: Turon-Lagot V

PROVIDER: S-EPMC7019876 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Targeting the Host for New Therapeutic Perspectives in Hepatitis D.

Turon-Lagot Vincent V Saviano Antonio A Schuster Catherine C Baumert Thomas F TF Verrier Eloi R ER

Journal of clinical medicine 20200114 1

Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV infected patients (60 million) are co-infected with HDV. Chronic hepatitis D is the most severe form of viral hepatitis with the highest risk to develop cirrhosis and liver cancer. Current treatment is based on pegylated-interferon-alpha which rarely controls HDV infection and is complicated by serious side effect ...[more]

PMID: 31947588

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