Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
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ABSTRACT:
SUBMITTER: Oggianu L
PROVIDER: S-EPMC7020267 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
Oggianu Laura L Ke Alice B AB Chetty Manoranjenni M Picollo Rossella R Petrucci Vanessa V Calisti Fabrizio F Garofolo Fabio F Tongiani Serena S
CPT: pharmacometrics & systems pharmacology 20200111 2
There is a paucity of clinical trials for the treatment of pediatric insomnia. This study was designed to predict the doses of trazodone to guide dosing in a clinical trial for pediatric insomnia using physiologically-based pharmacokinetic (PBPK) modeling. Data on the pharmacokinetics of trazodone in children are currently lacking. The interaction potential between trazodone and atomoxetine was also predicted. Doses predicted in the following age groups, with exposures corresponding to adult dos ...[more]
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