Ontology highlight
ABSTRACT:
SUBMITTER: Zamora AE
PROVIDER: S-EPMC7020562 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zamora Anthony E AE Crawford Jeremy Chase JC Allen E Kaitlynn EK Guo Xi-Zhi J XJ Bakke Jesse J Carter Robert A RA Abdelsamed Hossam A HA Moustaki Ardiana A Li Yongjin Y Chang Ti-Cheng TC Awad Walid W Dallas Mari H MH Mullighan Charles G CG Downing James R JR Geiger Terrence L TL Chen Taosheng T Green Douglas R DR Youngblood Benjamin A BA Zhang Jinghui J Thomas Paul G PG
Science translational medicine 20190601 498
Cancer arises from the accumulation of genetic alterations, which can lead to the production of mutant proteins not expressed by normal cells. These mutant proteins can be processed and presented on the cell surface by major histocompatibility complex molecules as neoepitopes, allowing CD8<sup>+</sup> T cells to mount responses against them. For solid tumors, only an average 2% of neoepitopes predicted by algorithms have detectable endogenous antitumor T cell responses. This suggests that low mu ...[more]