Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study.
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ABSTRACT:
SUBMITTER: Adams CD
PROVIDER: S-EPMC7020919 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study.
Clinical interventions in aging 20200210
<h4>Background</h4>Alzheimer's disease is a devastating neurodegenerative disorder. Its worldwide prevalence is over 24 million and is expected to double by 2040. Finding ways to prevent its cognitive decline is urgent.<h4>Methods</h4>A two-sample Mendelian randomization study was performed instrumenting glutamine, which is abundant in blood, capable of crossing the blood-brain barrier, and involved in a metabolic cycle with glutamate in the brain.<h4>Results</h4>The results reveal a protective ...[more]
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