Ontology highlight
ABSTRACT:
SUBMITTER: Norkett R
PROVIDER: S-EPMC7021487 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Norkett Rosalind R Del Castillo Urko U Lu Wen W Gelfand Vladimir I VI
eLife 20200205
Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding - the transport of microtubules along each other. We have recently demonstrated that a 'mitotic' kinesin-6 (Pavarotti in <i>Drosophila</i>) effectively inhibits microtubule-sliding and neurite outgrowth. However, mechanisms regulating Pavarotti itself in interphase cells and specifically in neurite outgrowth are unknown. Here, we use a combination of live imaging and bioch ...[more]