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ABSTRACT: Objective
To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.Methods
Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland-Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements.Results
For the first visit, RBF was 362?±?57 and 140?±?47 mL/min/100 g, and ATT was 0.47?±?0.13 and 0.70?±?0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201?±?72 and 84?±?27 mL/min/100 g, and ATT was 0.71?±?0.25 and 0.86?±?0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR.Discussion
This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.
SUBMITTER: Harteveld AA
PROVIDER: S-EPMC7021666 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Harteveld Anita A AA de Boer Anneloes A Franklin Suzanne Lisa SL Leiner Tim T van Stralen Marijn M Bos Clemens C
Magma (New York, N.Y.) 20191206 1
<h4>Objective</h4>To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.<h4>Methods</h4>Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) we ...[more]