Ontology highlight
ABSTRACT:
SUBMITTER: Spierling S
PROVIDER: S-EPMC7021713 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Spierling Samantha S de Guglielmo Giordano G Kirson Dean D Kreisler Alison A Roberto Marisa M George Olivier O Zorrilla Eric P EP
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20191008 4
Compulsive eating characterizes many binge-related eating disorders, yet its neurobiological basis is poorly understood. The insular cortex subserves visceral-emotional functions, including taste processing, and is implicated in drug craving and relapse. Here, via optoinhibition, we implicate projections from the anterior insular cortex to the nucleus accumbens as modulating highly compulsive-like food self-administration behaviors that result from intermittent access to a palatable, high-sucros ...[more]