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Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI.

ABSTRACT: To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus project, which was initiated by the European Cooperation in Science and Technology Action PARENCHIMA CA16103. Consensus recommendations were formulated using a two-step modified Delphi method. The first survey consisted of 56 items on T1 mapping, of which 4 reached the pre-defined consensus threshold of 75% or higher. The second survey was expanded to include both T1 and T2 mapping, and consisted of 54 items of which 32 reached consensus. Recommendations based were formulated on hardware, patient preparation, acquisition, analysis and reporting. Consensus-based technical recommendations for renal T1 and T2 mapping were formulated. However, there was considerable lack of consensus for renal T1 and particularly renal T2 mapping, to some extent surprising considering the long history of relaxometry in MRI, highlighting key knowledge gaps that require further work. This paper should be regarded as a first step in a long-term evidence-based iterative process towards ever increasing harmonization of scan protocols across sites, to ultimately facilitate clinical implementation.

SUBMITTER: Dekkers IA

PROVIDER: S-EPMC7021750 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI.

Dekkers Ilona A IA de Boer Anneloes A Sharma Kaniska K Cox Eleanor F EF Lamb Hildo J HJ Buckley David L DL Bane Octavia O Morris David M DM Prasad Pottumarthi V PV Semple Scott I K SIK Gillis Keith A KA Hockings Paul P Buchanan Charlotte C Wolf Marcos M Laustsen Christoffer C Leiner Tim T Haddock Bryan B Hoogduin Johannes M JM Pullens Pim P Sourbron Steven S Francis Susan S

Magma (New York, N.Y.) 20191122 1

To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus project, which was initiated by the European Cooperation in Science and Technology Action PARENCHIMA CA16103. Consensus recommendations were formulated using a two-step modified Delphi method. The first survey consisted of 56 items o ...[more]

PMID: 31758418

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Project description:BackgroundPhase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool.PurposeTo build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies.Study typeSystematic consensus process using a modified Delphi method.PopulationNot applicable.Sequence field/strengthRenal fast gradient echo-based 2D PC-MRI.AssessmentAn international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4-10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated.Statistical testsConsensus was defined as ≥75% unanimity in response, and a clear preference was defined as 60-74% agreement among the experts.ResultsAmong 60 statements, 57 (95%) achieved consensus after the second-round survey, while the remaining three showed a clear preference. Consensus statements resulted in specific recommendations for subject preparation, 2D renal PC-MRI data acquisition, processing, and reporting.Data conclusionThese recommendations might promote a widespread adoption of renal PC-MRI, and may help foster the set-up of multicenter studies aimed at defining reference values and building larger and more definitive evidence, and will facilitate clinical translation of PC-MRI.Level of evidence1 TECHNICAL EFFICACY STAGE: 1.

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Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI.

Publications

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI.

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