Ontology highlight
ABSTRACT:
SUBMITTER: Oueslati S
PROVIDER: S-EPMC7022249 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Oueslati Saoussen S Retailleau Pascal P Marchini Ludovic L Dortet Laurent L Bonnin Rémy A RA Iorga Bogdan I BI Naas Thierry T
Microorganisms 20191221 1
OXA-48-producing Enterobacterales have now widely disseminated globally. A sign of their extensive spread is the identification of an increasing number of OXA-48 variants. Among them, three are particularly interesting, OXA-163, OXA-247 and OXA-405, since they have lost carbapenem activities and gained expanded-spectrum cephalosporin hydrolytic activity subsequent to a four amino-acid (AA) deletion in the β5-β6 loop. We investigated the mechanisms responsible for substrate specificity of OXA-405 ...[more]