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The Overexpression of T?4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development.


ABSTRACT: Increased cashmere yield and improved quality are some goals of cashmere goat breeding. Thymosin beta-4 (T?4) plays a key role in the growth and development of hair follicles. For the past ten years, we have evaluated the role of T?4 by establishing a flock of 15 cashmere goats that specifically overexpress the T?4 gene in the hair follicles. These T?4 overexpression (T?4-OE) cashmere goats had more secondary hair follicles than the WT goats and produced more cashmere. Meanwhile, combined analysis of the skin transcriptome and proteome in cashmere goats suggested that T?4 may affect hair growth by interacting with keratin type II cytoskeletal 4 epidermal (KRT4) to mediate the extracellular signal-regulated protein kinase (ERK) signaling pathway, thereby promoting the development of secondary hair follicles, and consequently, increasing cashmere yield. Thus, the specific overexpression of T?4 in the hair follicles of cashmere goats effectively increased the cashmere yield.

SUBMITTER: Dai B 

PROVIDER: S-EPMC7022706 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development.

Dai Bai B   Liang Hao H   Guo Dong-Dong DD   Bi Zhao-Wei ZW   Yuan Jian-Long JL   Jin Yong Y   Huan Lei L   Guo Xu-Dong XD   Cang Ming M   Liu Dong-Jun DJ  

Animals : an open access journal from MDPI 20191231 1


Increased cashmere yield and improved quality are some goals of cashmere goat breeding. Thymosin beta-4 (Tβ4) plays a key role in the growth and development of hair follicles. For the past ten years, we have evaluated the role of Tβ4 by establishing a flock of 15 cashmere goats that specifically overexpress the <i>Tβ4</i> gene in the hair follicles. These Tβ4 overexpression (Tβ4-OE) cashmere goats had more secondary hair follicles than the WT goats and produced more cashmere. Meanwhile, combined  ...[more]

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