Ontology highlight
ABSTRACT:
SUBMITTER: Beck C
PROVIDER: S-EPMC7023129 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Beck Carole C Castañeda-Zegarra Sergio S Huse Camilla C Xing Mengtan M Oksenych Valentyn V
Biomolecules 20191230 1
DNA double-strand breaks (DSBs) trigger the Ataxia telangiectasia mutated (ATM)-dependent DNA damage response (DDR), which consists of histone H2AX, MDC1, RNF168, 53BP1, PTIP, RIF1, Rev7, and Shieldin. Early stages of B and T lymphocyte development are dependent on recombination activating gene (RAG)-induced DSBs that form the basis for further V(D)J recombination. Non-homologous end joining (NHEJ) pathway factors recognize, process, and ligate DSBs. Based on numerous loss-of-function studies, D ...[more]