Unknown

Dataset Information

0

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.


ABSTRACT: Developing multifunctional and biocompatible drug delivery nanoplatforms that integrate high drug loads and multiple imaging modalities avoiding cross-interferences is extremely challenging. Here we report on the successful chemical reaction of the high quantum yield biodegradable and photoluminescent polyester (BPLP) with the poly(lactic-co-glycolic acid) (PLGA) polymer to fabricate biocompatible photoluminescent nanocapsules (NCs). Furthermore, we transform the PLGA-BPLP NCs into a magnetic resonance (MR)/photoluminescence dual-modal imaging theranostic platform by incorporating superparamagnetic iron oxide nanoparticles (SPIONs) into the polymeric shell. In vitro phantoms confirmed the excellent MRI-r2 relaxivity values of the NCs whilst the cellular uptake of these NCs was clearly observed by fluorescence optical imaging. Besides, the NCs (mean size ~270 nm) were loaded with ~1 wt% of a model protein (BSA) and their PEGylation provided a more hydrophilic surface. The NCs show biocompatibility in vitro, as hCMEC/D3 endothelial cells viability was not affected for particle concentration up to 500 ?g/mL. Interestingly, NCs decorated with SPIONs can be exploited for magnetic guiding and retention.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7023350 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.

Zhang Yajie Y   García-Gabilondo Miguel M   Rosell Anna A   Roig Anna A  

Pharmaceutics 20191221 1


Developing multifunctional and biocompatible drug delivery nanoplatforms that integrate high drug loads and multiple imaging modalities avoiding cross-interferences is extremely challenging. Here we report on the successful chemical reaction of the high quantum yield biodegradable and photoluminescent polyester (BPLP) with the poly(lactic-co-glycolic acid) (PLGA) polymer to fabricate biocompatible photoluminescent nanocapsules (NCs). Furthermore, we transform the PLGA-BPLP NCs into a magnetic re  ...[more]

Similar Datasets

| S-EPMC5473604 | biostudies-literature
| S-EPMC3988683 | biostudies-literature
| S-EPMC6091499 | biostudies-literature
| S-EPMC5464824 | biostudies-literature
| S-EPMC4464533 | biostudies-literature
| S-EPMC5880337 | biostudies-literature
| S-EPMC9063760 | biostudies-literature
| S-EPMC9749127 | biostudies-literature
| S-EPMC4737722 | biostudies-literature
| S-EPMC9669590 | biostudies-literature