Dataset Information

Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma.

ABSTRACT: Objective:To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. Methods:A total of 175 patients with HCC were enrolled. Patients' characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. Results:The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group (P?=?0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% (P?=?0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival (P?=?0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival (P?=?0.0018). The multivariate analysis results indicated that TNM stage (HR?=?1.541, 95%CI 1.072-2.412, P?=?0.002) and HBV infection (HR?=?1.087, 95%CI 1.012-1.655, P?=?0.042) were independent risk variables for overall survival. While vascular invasion (HR?=?1.562, 95%CI 1.013-2.815, P?=?0.042) and HBV infection (HR?=?1.650, 95%CI 1.017-2.676, P?=?0.037) were independent risk factors associated with disease-free survival. Conclusion:Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis.

SUBMITTER: Xue X

PROVIDER: S-EPMC7023697 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma.

Xue Xiulan X Liao Wei W Xing Yugang Y

Infectious agents and cancer 20200214

<h4>Objective</h4>To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis.<h4>Methods</h4>A total of 175 patients with HCC were enrolled. Patients' characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab.<h4>Results</h4>The patient ...[more]

PMID: 32082414

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Project description:BackgroundThe gut-liver axis plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC). However, the correlations between the gut microbiome and the liver tumor transcriptome in patients with HCC and the impact of the gut microbiota on clinical outcome are less well-understood.MethodsFecal samples collected from HBV-related HCC patients (n = 113) and healthy volunteers (n = 100) were subjected to 16S rRNA sequencing of the microbiome. After a rigorous selection process, 32 paired tumor and adjacent non-tumor liver tissues from the HCC group were subjected to next-generation sequencing (NGS) RNA-seq. The datasets were analyzed individually and integrated with clinical characteristics for combined analysis using bioinformatics approaches. We further verified the potential of the gut microbiota to predict clinical outcome by a random forest model and a support vector machine model.ResultsWe found that Bacteroides, Lachnospiracea incertae sedis, and Clostridium XIVa were enriched in HCC patients with a high tumor burden. By integrating the microbiome and transcriptome, we identified 31 robust associations between the above three genera and well-characterized genes, indicating possible mechanistic relationships in tumor immune microenvironment. Clinical characteristics and database analysis suggested that serum bile acids may be important communication mediators between these three genera and the host transcriptome. Finally, among these three genera, six important microbial markers associated with tumor immune microenvironment or bile acid metabolism showed the potential to predict clinical outcome (AUC = 81%).ConclusionsThis study revealed that changes in tumor immune microenvironment caused by the gut microbiota via serum bile acids may be important factors associated with tumor burden and adverse clinical outcome. Gut microbes can be used as biomarkers of clinical features and outcomes, and the microbe-associated transcripts of host tumors can partly explain how gut microbiota promotes HCC pathogenesis.

Dataset Information

Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma.

Publications

Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma.

Similar Datasets

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