Ontology highlight
ABSTRACT:
SUBMITTER: Bermeo R
PROVIDER: S-EPMC7024360 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bermeo Rafael R Bernardi Anna A Varrot Annabelle A
Molecules (Basel, Switzerland) 20200107 2
Lectins mediate adhesion of pathogens to host tissues, filling in a key role in the first steps of infection. Belonging to the opportunistic pathogen <i>Burkholderia</i> <i>cenocepacia</i>, BC2L-C is a superlectin with dual carbohydrate specificity, believed to mediate cross-linking between bacteria and host cells. Its C-terminal domain binds to bacterial mannosides while its N-terminal domain (BCL2-CN) recognizes fucosylated human epitopes. BC2L-CN presents a tumor necrosis factor alpha (TNF-) ...[more]