Ontology highlight
ABSTRACT:
SUBMITTER: Colunga Biancatelli RML
PROVIDER: S-EPMC7024751 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Colunga Biancatelli Ruben Manuel Luciano RML Berrill Max M Mohammed Yassen H YH Marik Paul E PE
Journal of thoracic disease 20200201 Suppl 1
Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial dysfunction are common features of septic patients that can cause multiorgan failure and death. Melatonin, alongside its traditionally accepted role as the master hormonal regulator of the circadian rhythm, is a promising adjunctive drug for sepsis through its ...[more]