A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation.
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ABSTRACT:
SUBMITTER: Charmetant X
PROVIDER: S-EPMC7025331 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation.
Charmetant Xavier X Teuma Cécile C Lake Jennifer J Dijoud Frédérique F Frochot Vincent V Deeb Abbas A
Clinical kidney journal 20190514 1
The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity. ...[more]
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