Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.
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ABSTRACT:
SUBMITTER: Gordon EM
PROVIDER: S-EPMC7025374 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.
Gordon Eric M EM Duncton Matthew A J MAJ Wang Brian J BJ Qi Longwu L Fan Dazhong D Li Xianfeng X Ni Zhi-Jie ZJ Ding Pingyu P Grygorash Ruslan R Low Eddy E Yu Guijun G Sun Jiawei J
ACS medicinal chemistry letters 20200108 2
Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam. ...[more]
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