HLA-E expression in diffuse glioma: relationship with clinicopathological features and patient survival.

ABSTRACT: BACKGROUND:Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression in glioma patients has not been elucidated. The current study aimed to investigate the association of HLA-E expression with clinicopathological features and survival in patients with diffuse glioma. METHODS:A total of 261 glioma patients were enrolled, subsequently, mRNA microarray analysis was conducted to identify the relationship of HLA-E with clinicopathological features and patient survival. RESULTS:HLA-E was significantly overexpressed in high-grade gliomas compared to low-grade gliomas (LGGs). Moreover, HLA-E expression was significantly higher in diffuse astrocytomas than oligodendrogliomas (p = 0.032, t-tes

SUBMITTER: Wu Z 

PROVIDER: S-EPMC7025409 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature