Ontology highlight
ABSTRACT:
SUBMITTER: Stephens K
PROVIDER: S-EPMC7025430 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Stephens Kristina K Zargar Amin A Emamian Milad M Abutaleb Nadia N Choi Erica E Quan David N DN Payne Gregory G Bentley William E WE
Biotechnology progress 20190810 6
The autoinducer-2 (AI-2) quorum sensing system is involved in a range of population-based bacterial behaviors and has been engineered for cell-cell communication in synthetic biology systems. Investigation into the cellular mechanisms of AI-2 processing has determined that overexpression of uptake genes increases AI-2 uptake rate, and genomic deletions of degradation genes lowers the AI-2 level required for activation of reporter genes. Here, we combine these two strategies to engineer an Escher ...[more]