Dataset Information

Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.

ABSTRACT: When confronted with a highly variable environment, it remains poorly understood how neural populations encode and classify natural stimuli to give rise to appropriate and consistent behavioral responses. Here we investigated population coding of natural communication signals with different attributes (i.e., amplitude and duration) in the electrosensory system of the weakly electric fish Apteronotus leptorhynchus. Our results show that, while single peripheral neurons encode the detailed timecourse of different stimulus waveforms, measures of population synchrony are effectively unchanged because of coordinated increases and decreases in activity. A phenomenological mathematical model reproduced this invariance and shows that this can be explained by considering homogeneous populations whose responses are solely determined by single neuron firing properties. Moreover, recordings from downstream central neurons reveal that synchronous afferent activity is actually decoded and thus most likely transmitted to higher brain areas. Finally, we demonstrate that the associated behavioral responses at the organism level are invariant. Our results provide a mechanism by which amplitude- and duration-invariant coding of behaviorally relevant sensory input emerges across successive brain areas thereby presumably giving rise to invariant behavioral responses. Such mechanisms are likely to be found in other systems that share anatomical and functional features with the electrosensory system (e.g., auditory, visual, vestibular).

SUBMITTER: Metzen MG

PROVIDER: S-EPMC7025533 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.

Metzen Michael G MG Hofmann Volker V Chacron Maurice J MJ

Frontiers in neuroscience 20200205

When confronted with a highly variable environment, it remains poorly understood how neural populations encode and classify natural stimuli to give rise to appropriate and consistent behavioral responses. Here we investigated population coding of natural communication signals with different attributes (i.e., amplitude and duration) in the electrosensory system of the weakly electric fish <i>Apteronotus leptorhynchus</i>. Our results show that, while single peripheral neurons encode the detailed ...[more]

PMID: 32116522

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Project description:Severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of LPC in liver physiology and in hepatic injury remains a contentious topic. We found that ductular reaction cells in human cirrhotic livers express hepatocyte nuclear factor 1 homeobox B (HNF1?). However, HNF1? expression was not present in newly generated epithelial cell adhesion molecule (EpCAM)-positive hepatocytes. In order to investigate the role of HNF1?-expressing cells we used a tamoxifen-inducible Hnf1?CreER/R26R(Yfp/LacZ) mouse to lineage-trace Hnf1?(+) biliary duct cells and to assess their contribution to LPC expansion and hepatocyte generation. Lineage tracing demonstrated no contribution of HNF1?(+) cells to hepatocytes during liver homeostasis in healthy mice or after loss of liver mass. After acute acetaminophen or carbon tetrachloride injury no contribution of HNF1?(+) cells to hepatocyte was detected. We next assessed the contribution of Hnf1?(+) -derived cells following two liver injury models with LPC expansion, a diethoxycarbonyl-1,4-dihydro-collidin (DDC)-diet and a choline-deficient ethionine-supplemented (CDE)-diet. The contribution of Hnf1?(+) cells to liver regeneration was dependent on the liver injury model. While no contribution was observed after DDC-diet treatment, mice fed with a CDE-diet showed a small population of hepatocytes derived from Hnf1?(+) cells that were expanded to 1.86% of total hepatocytes after injury recovery. Genome-wide expression profile of Hnf1?(+) -derived cells from the DDC and CDE models indicated that no contribution of LPC to hepatocytes was associated with LPC expression of genes related to telomere maintenance, inflammation, and chemokine signaling pathways.HNF1?(+) biliary duct cells are the origin of LPC. HNF1?(+) cells do not contribute to hepatocyte turnover in the healthy liver, but after certain liver injury, they can differentiate to hepatocytes contributing to liver regeneration.

Dataset Information

Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.

Publications

Neural Synchrony Gives Rise to Amplitude- and Duration-Invariant Encoding Consistent With Perception of Natural Communication Stimuli.

Similar Datasets

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