Ontology highlight
ABSTRACT:
SUBMITTER: Aliseychik M
PROVIDER: S-EPMC7025544 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200129
The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TRGs in patients with AD and control patients without dementia. TRG clones were clearly detectable in peripheral blood (PB) and non-neuronal cell populations in human brains. TRG repertoire diversity was red ...[more]