Ontology highlight
ABSTRACT:
SUBMITTER: Burada AP
PROVIDER: S-EPMC7025878 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20200110 1
Ionotropic orphan delta (GluD) receptors are not gated by glutamate or any other endogenous ligand but are grouped with ionotropic glutamate receptors (iGluRs) based on sequence similarity. GluD1 receptors play critical roles in synaptogenesis and synapse maintenance and have been implicated in neuronal disorders, including schizophrenia, cognitive deficits, and cerebral ataxia. Here we report cryo-EM structures of the rat GluD1 receptor complexed with calcium and the ligand 7-chlorokynurenic ac ...[more]