Dataset Information

High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly.

ABSTRACT: Normative brain atlases are a standard tool for neuroscience research and are, for example, used for spatial normalization of image datasets prior to voxel-based analyses of brain morphology and function. Although many different atlases are publicly available, they are usually biased with respect to an imaging modality and the age distribution. Both effects are well known to negatively impact the accuracy and reliability of the spatial normalization process using non-linear image registration methods. An important and very active neuroscience area that lacks appropriate atlases is lesion-related research in elderly populations (e.g. stroke, multiple sclerosis) for which FLAIR MRI and non-contrast CT are often the clinical imaging modalities of choice. To overcome the lack of atlases for these tasks and modalities, this paper presents high-resolution, age-specific FLAIR and non-contrast CT atlases of the elderly generated using clinical images.

SUBMITTER: Rajashekar D

PROVIDER: S-EPMC7026039 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly.

Rajashekar Deepthi D Wilms Matthias M MacDonald M Ethan ME Ehrhardt Jan J Mouches Pauline P Frayne Richard R Hill Michael D MD Forkert Nils D ND

Scientific data 20200217 1

Normative brain atlases are a standard tool for neuroscience research and are, for example, used for spatial normalization of image datasets prior to voxel-based analyses of brain morphology and function. Although many different atlases are publicly available, they are usually biased with respect to an imaging modality and the age distribution. Both effects are well known to negatively impact the accuracy and reliability of the spatial normalization process using non-linear image registration me ...[more]

PMID: 32066734

Similar Datasets

Project description:Articular cartilage lines the load-bearing surfaces of long bones and undergoes compositional and structural degeneration during osteoarthritis progression. Contrast enhanced microcomputed tomography (?CT) is being applied to a variety of preclinical models, including the mouse, to map structural and compositional properties in 3-D. The thinness (?30-50??m) and high cellularity of mouse articular cartilage presents a significant imaging challenge. Our group previously showed that mouse articular cartilage and proteoglycan (PG) content can be assessed by ?CT with the ioxagalate-based contrast agent Hexabrix, but the voxel size used (6??m) was deemed to be barely adequate. The objective of the present study is to assess the utility of a novel contrast agent, CA4+, to quantify mouse articular cartilage morphology and composition with high resolution ?CT imaging (3??m voxels) and to compare the sensitivity of CA4+ and Hexabrix to detect between-group differences. While both contrast agents are iodine-based, Hexabrix is anionic and CA4+ is cationic so they interact differently with negatively charged PGs. With CA4+, a strong correlation was found between non-calcified articular cartilage thickness measurements made with histology and ?CT (R2 ?=?0.72, p?<?0.001). Cartilage degeneration-as assessed by loss in volume, thickness, and PG content-was observed in 34-week-old mice when compared to both 7- and 12-week-old mice. High measurement precision was observed with CA4+, with the coefficient of variation after repositioning and re-imaging samples equaling 2.8%, 4.5%, 7.4% and 5.9% for attenuation, thickness, volume, and PG content, respectively. Use of CA4+ allowed increased sensitivity for assessing PG content compared to Hexabrix, but had no advantage for measurement of cartilage thickness or volume. This improvement in imaging should prove useful in preclinical studies of cartilage degeneration and regeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2740-2748, 2017.

Dataset Information

High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly.

Publications

High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets